CINCINNATI (AP) — Jurickson Profar hit a three-run homer, MacKenzie Gore struck out 10 over five innings and the San Diego Padres beat the Cincinnati Reds 8-5 Wednesday night.

Gore (2-0) allowed a run on five hits as the Padres won for the seventh time in nine games. Eric Hosmer drove in two runs, including a leadoff homer in the eighth.

San Diego will go for its second sweep of the season Thursday of the hard-luck Reds, who have lost 12 of 13 amid a rash of injuries and slumps. Cincinnati’s 3-15 record in the worst in the majors.

Reds starter Vladimir Gutierrez (0-4) went four innings and was charged with six runs and five hits, walking six and striking out two.

Gutierrez walked the bases full with one out in the second, but he allowed just one run on Luis Campusano’s sacrifice fly, striking out C.J. Abrams to end the threat.

There was more trouble in the third when Trent Grisham led off the with a triple and scored on a bloop single by Jake Cronenworth. After another blooper by Manny Machado, Profar homered into the first row of seats in right field to put San Diego up 5-0.

Machado had three hits.

In the Reds third, Tommy Pham singled and tried to score from first on Kyle Farmer’s two-out double to left. He was called out at the plate, but Cincinnati challenged the call. The replay showed Pham got his left hand to the plate just before the tag.

Pham also had a solo homer in the seventh. Farmer had four doubles and two RBIs.

Brandon Drury hit a one-out solo homer in the ninth, and Farmer’s fourth two-bagger drove in another run with two outs. Padres reliever Taylor Rogers got Jake Fraley to fly out to right with two runners on for the save.

TRAINERS ROOM

Padres: OF Wil Myers was out after aggravating a bruise between his right thumb and index finger in Tuesday night’s game.

Reds: Manager David Bell said 3B Mike Moustakas (right biceps strain) likely will be activated from the injury list Thursday and could be used as a pinch hitter. … LHP Justin Wilson (elbow soreness) was placed on the 10-day injured list Wednesday, the 15th player to appear on the list this season.

UP NEXT

The Reds send Tyler Mahle (1-2) against Padres right-hander Nick Martinez (0-2) in the series finale Thursday afternoon.

___

More AP MLB: https://apnews.com/hub/MLB and https://twitter.com/AP_Sports

San Diego Padres’ Jurickson Profar, left, attempts to dive back to third base and is tagged out by Cincinnati Reds’ Matt Reynolds during the fifth inning of a baseball game in Cincinnati, Wednesday, April 27, 2022. (AP Photo/Aaron Doster)

https://www.wnewsj.com/wp-content/uploads/sites/22/2022/04/web1_128712227-961ae1d0640b420ba1aea26894be5b00.jpgSan Diego Padres’ Jurickson Profar, left, attempts to dive back to third base and is tagged out by Cincinnati Reds’ Matt Reynolds during the fifth inning of a baseball game in Cincinnati, Wednesday, April 27, 2022. (AP Photo/Aaron Doster)

San Diego Padres’ MacKenzie Gore throws during the second inning of a baseball game against the Cincinnati Reds in Cincinnati, Wednesday, April 27, 2022. (AP Photo/Aaron Doster)

https://www.wnewsj.com/wp-content/uploads/sites/22/2022/04/web1_128712227-3dd22a2063ca47debd4970490fabaadb.jpgSan Diego Padres’ MacKenzie Gore throws during the second inning of a baseball game against the Cincinnati Reds in Cincinnati, Wednesday, April 27, 2022. (AP Photo/Aaron Doster)

Cincinnati Reds’ Tommy Pham, left, is safe at home plate ahead of the tag by San Diego Padres’ Austin Nola during the third inning of a baseball game in Cincinnati, Wednesday, April 27, 2022. (AP Photo/Aaron Doster)

https://www.wnewsj.com/wp-content/uploads/sites/22/2022/04/web1_128712227-8b248578f86544d2b34c42522539dbc4.jpgCincinnati Reds’ Tommy Pham, left, is safe at home plate ahead of the tag by San Diego Padres’ Austin Nola during the third inning of a baseball game in Cincinnati, Wednesday, April 27, 2022. (AP Photo/Aaron Doster)